The objective of the course is to familiarize students with the contemporary trends in individualized medicine and pharmacotherapy based on genetics and genomics; to clarify the concept of personalised medicine; to explain the pharmacogenetic and pharmacogenetic approach to humans, disease and therapy; to illustrate the examples from clinical practice; to introduce students to basic concepts, procedures, phases and technologies present in the drug research process.
Pharmacology at the turn of the millennium. Genome, protein, biom, systems biology. Introduction to basic concepts related to personal medicine. Gene variability, importance of SNPs and haplotypes. Pharmacogenetics – the role of genetic variation in drug metabolism and transport. Pharmacogenomics – controlled clinical trials. Application of these approaches in different areas of medicine. How to create a new and better medicine with the help of everything learned and in the context of continuous learning about genetic variability? Translational medicine. Ethical issues.
Obavezna literatura:
- Dostupna predavanja; Literaturu će osigurati predavač.
Dopunska literatura:
- Cowie P, Hay EA, MacKenzie A. The noncoding human genome and the future of personalised medicine. Expert Rev Mol Med. 2015:17:e4.
- Rasool M, Malik A, Naseer MI, Ansari SA, Begum I, Quazi MH, i sur. The role of epigenetics in personalized medicine: challenges and opportunities. BMC Med Genomics. 2015;8(Suppl 1):S5.
- Ciardiello F, Arnold D, Casali PG, Cervantes A, Douillard JY, Eggermont A, i sur. Delivering precision medicine in oncology today and in future – the promise and challenges of personalised cancer medicine: a position paper by the European Society for Medical Oncology (ESMO). Ann Oncol. 2014;25(9):1673-1678.
- Chan SL, Jin S, Loh M, Brunham LR. Progress in understanding the genomic basis for adverse drug reactions: a comprehensive review and focus on the role of ethnicity. Pharmacogenomics. 2015;16(10):1161-78.
- Druge relevantne publikacije u trenutku održavanja nastave.
Upon completion of this course, students will be able to:
1. Support modern trends in personalized medicine, pharmacotherapy, drug discovery and choosing more specific drugs.
2. Assess the impact of genetic variability on the effect of the drug and on its basic mechanism of action and compare it with the aim of personalized therapy in the process of new drugs discovery and its clinical use;
3. Rank specific sources of test variability that are set in order to provide insight into them.
4. Support the openness for continued learning and application of individualized medicine into their work environment and their field of work.